Research library
Low-dose naltrexone, explained
12 guides, organized by the question you are trying to answer.
Research Guides
Low-dose naltrexone in chronic pain and other conditions: reviews and studies
What randomized trials, observational cohorts and reviews report about low-dose naltrexone in chronic pain and other conditions, with their limits.
Low-dose naltrexone and Crohn's disease: what the trials and the Cochrane review measured
What the Cochrane review and three trials of low-dose naltrexone in Crohn's disease measured, with doses, sizes and disclosures.
Low-dose naltrexone and fibromyalgia: what the trials and reviews measured
What six fibromyalgia trials of low-dose naltrexone measured, what four reviews concluded, and the limits of both.
Low-dose naltrexone and multiple sclerosis: what the studies measured
What three published abstracts report about low-dose naltrexone in multiple sclerosis: doses, designs, sizes, dropouts and the authors' own limits.
Naltrexone, pregnancy and breastfeeding: what the 50 mg label says
What the 50 mg naltrexone label says about pregnancy, animal data and breastfeeding; it does not cover low-dose naltrexone.
Liver, mood and other warnings: what the 50 mg naltrexone label says
What the 50 mg naltrexone label says about liver injury, depression and symptoms to report; low-dose use is not covered.
What the prescribing information for naltrexone hydrochloride 50 mg tablets says
What the label for the 50 mg naltrexone tablet says about its use, its dosing and the opioid-free period before starting, not about low-dose use.
Opioids and naltrexone: what the 50 mg label and two overdose pages say
What the 50 mg naltrexone label says about precipitated withdrawal, overdose and opioid-containing medicines, plus two general overdose pages.
Low-dose naltrexone side effects: what trials, reviews and the 50 mg label report
What low-dose naltrexone trials, reviews and observational studies report about side effects, with the 50 mg label's figures kept separate.
What compounded Low-dose naltrexone means: what the FDA says and what was tested
What FDA pages say compounded drugs are and are not, how section 503A is described, and what two laboratory analyses of compounded capsules reported.
What Low-dose naltrexone is and how it might work
What low-dose naltrexone is, how review abstracts say it might work, and why it is an off-label use separate from the 50 mg tablet.
What off-label use means and when to see a clinician
What the FDA says about off-label use, what MedlinePlus and drug labels list for three conditions, and the emergency steps the sources give.
